The Rodriguez Laboratory
The Full Story
Publications
Learning Deformable 3D Graphs Similarity to Track Plant Cells in Unregistered Time Lapse Images
HAIRY MERISTEM proteins regulate the WUSCHEL protein levels in mediating CLAVATA3 expression
Kevin Rodriguez, Lloyd Kao, Vincent E Cerbantez-Bueno, Christian Delgadillo, Dorothy Nguyen, Samin Ullah, Cameron Delgadillo, G Venugopala Reddy
Md Shazid Islam, Arindam Dutta, Calvin-Khang Ta, Kevin Rodriguez, Christian Michael, Mark Alber, G Venugopala Reddy, Amit K Roy-Chowdhury
Role of turgor-pressure induced boundary tension in the maintenance of the shoot apical meristem of Arabidopsis thaliana.
Michael, Christian, Mikahl Banwarth-Kuhn, Kevin Rodriguez, Calvin-Khang Ta, Amit K Roy-Chowhurry, Weitao Chen, G. Venugopala Reddy, and Mark Alber. 2023. Journal of the Royal Society Interface 20(203):20230173
Concentration-dependent transcriptional switching through a collective action of cis-elements.
Kevin Rodriguez, Albert Do, Betul Senay-Aras, Mariano Perales, Mark Alber, Weitao Chen,
and G. Venugopala Reddy. 2023. Science Advances 8(31):eabo6157
5 / Modeling of SAM shape maintenance
Banwarth-Kuhn M, Rodriguez K, Michael C, Ta C-K, Plong A, Bourgain-Chang E, et al. (2022) Combined computational modeling and experimental analysis integrating chemical and mechanical signals suggests possible mechanism of shoot meristem maintenance. PLoS Comput Biol 18(6): e1010199. https://doi.org/10.1371/journal.pcbi.1010199
6 / CLV3 Regulation of WUS
Plong, A., Rodriguez, K., Alber, M. et al. CLAVATA3 mediated simultaneous control of transcriptional and post-translational processes provides robustness to the WUSCHEL gradient. Nat Commun 12, 6361 (2021). https://doi.org/10.1038/s41467-021-26586-0
7 / Maintenance of SAM shape and structure
Banwarth-Kuhn, M., Nematbakhsh, A., Rodriguez, K.W. et al. Cell-Based Model of the Generation and Maintenance of the Shape and Structure of the Multilayered Shoot Apical Meristem of Arabidopsis thaliana. Bull Math Biol 81, 3245–3281 (2019). https://doi.org/10.1007/s11538-018-00547-z
8 / Cytokinin Regulation of WUS
Snipes SA, Rodriguez K, DeVries AE, Miyawaki KN, Perales M, et al. (2018) Cytokinin stabilizes WUSCHEL by acting on the protein domains required for nuclear enrichment and transcription. PLOS Genetics 14(4): e1007351. https://doi.org/10.1371/journal.pgen.1007351
9 / WUS regulation of CLV3
Perales M, Rodriguez K, Snipes S, Yadav RK, Diaz-Mendoza M, G. V. Reddy, Threshold-dependent transcriptional discrimination underlies stem cell homeostasis. Proc. Natl. Acad. Sci. U.S.A. 113, E6298–E6306 (2016).
10 / WUS protein regulation
Rodriguez K, Perales M, Snipes S, Yadav RK, Diaz-Mendoza M, G. V. Reddy, DNA-dependent homodimerization, sub-cellular partitioning, and protein destabilization control WUSCHEL levels and spatial patterning. Proc. Natl. Acad. Sci. U.S.A. 113, E6307–E6315 (2016).